Lowering GTP level increases survival of amino acid starvation but slows growth rate of 3
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چکیده
1 2 Lowering GTP level increases survival of amino acid starvation but slows growth rate of 3 Bacillus subtilis cells lacking (p)ppGpp 4 5 RUNNING TITLE 6 Quantitative relationship between GTP and growth 7 8 9 Alycia N. Bittner , Allison Kriel, and Jue D. Wang # 10 11 Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706 12 13 Present address: Department of Biology, Stanford University, Stanford, CA 94305 14 15 16 17 Corresponding author: [email protected], [email protected] 18 19 JB Accepts, published online ahead of print on 28 March 2014 J. Bacteriol. doi:10.1128/JB.01471-14 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
منابع مشابه
Lowering GTP level increases survival of amino acid starvation but slows growth rate for Bacillus subtilis cells lacking (p)ppGpp.
Bacterial cells sense external nutrient availability to regulate macromolecular synthesis and consequently their growth. In the Gram-positive bacterium Bacillus subtilis, the starvation-inducible nucleotide (p)ppGpp negatively regulates GTP levels, both to resist nutritional stress and to maintain GTP homeostasis during growth. Here, we quantitatively investigated the relationship between GTP l...
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